In aesthetics, botulinum neurotoxin is used to temporarily reduce the appearance of fine lines and wrinkles by paralyzing the muscles that cause them. The most well-known form of botulinum neurotoxin used for aesthetics is Botox, Dysport, and Xeomin.

When injected into specific muscles, the neurotoxin blocks the release of acetylcholine, a chemical messenger that triggers muscle contractions. This leads to temporary muscle paralysis and a smoothing of the skin surface. Botulinum neurotoxin injections are commonly used on the forehead, between the eyebrows, around the eyes, and around the mouth.

The effects of botulinum neurotoxin injections for aesthetics typically last for three to six months, after which the treatment can be repeated to maintain the desired results.